Oral Presentation ANZOS-Breakthrough Discoveries Joint Annual Scientific Meeting 2018

Comparing Two Exercise Training Doses on Metabolic Control in Adults with Overweight/Obesity and Type 2 Diabetes: A Randomised Controlled Trial   (#80)

Trishan Gajanand 1 , Shelley E Keating 1 , Wendy J Brown 1 , Matthew D Hordern 1 , Emily Cox 1 , Robert G Fassett 1 , Jeff S Coombes 1
  1. School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Queensland, Australia

Background: Moderate intensity continuous aerobic training with moderate intensity resistance training (C-MICT) has been shown to improve insulin sensitivity and beta-cell function in people with type 2 diabetes mellitus (T2D). The combination of high-intensity interval aerobic training with high-intensity resistance training (C-HIIT) has not been previously investigated in people with T2D. We aimed to compare the efficacy of 8 weeks of low volume C-HIIT and C-MICT on beta-cell function, insulin sensitivity (IS) and resistance (IR), fasting plasma blood glucose (FPG) and insulin (FPI) in adults with T2D.

Methods: Forty-three adults (60±7y) with overweight/obesity (BMI=33.4±6.6kg/m2) and T2D (glycated haemoglobin [HbA1c] 61±13 mmol/mol [7.7±1.2%]) were randomised into 8wks of either: low volume C-HIIT (n=15), C-MICT (n=16), or control (n=12). C-HIIT involved aerobic exercise for 4min at 85-95% peak heart rate (HRpeak) followed by high-intensity resistance training (Rate of Perceived Exertion [RPE] ≥17) involving 8 exercises for 1-min each, on three days/week. Session time was 26mins = 78mins/week. C-MICT comprised aerobic exercise for 150mins/wk over four days at 55-69% HRpeak and moderate intensity resistance training 60mins/wk (RPE 11-13). Total exercise time = 210 mins/week. Blood samples were taken after an overnight fast with the homeostatic model assessment 2 (HOMA2) used as an indicator of beta-cell function, IS and IR. ANCOVA was used to determine differences in change scores between groups using the baseline value as the covariate. Values are reported as means±SD.

Results: There were no significant between-group difference for change in beta-cell function (5.43±25.81%, 0.93±31.51%, and 15.23±77.06% for C-HIIT, C-MICT and control, respectively), IS (-1.36±23.34%, -1.49±32.86%, 2.17±9.90%), IR (0.45±0.82, -0.36±1.74, 0.04±0.90), FPG (0.24±2.66mmol/l, -0.89±2.96mmol/l, 0.42±3.09mmol/l) and FPI (3.23±5.95µU/ml, -1.68±9.87µU/ml, 0.87±7.87µU/ml).

Conclusion: The novel findings from this study are that 8 weeks of low volume C-HIIT and C-MICT did not significantly improve metabolic control in adults with T2D.

Trial Registration: ACTRN12615000475549.