Tuesday, 16th October ANZOS-Breakthrough Discoveries Joint Annual Scientific Meeting 2018

• Systems genetics approaches to map new genes in metabolism and aging - Johan Auwerx

• The personal burden of stigma, bias and responsibility for obesity - John Dixon
• Diet as a shared risk factor for obesity and common mental disorders - Michael Berk
• Early life stress and subsequent obesity in women - Jayashri Kulkarni

Followed by 30 minute Q&A discussion

• Bile acid signaling and control of mitochondrial metabolism - Kristina Schoonjans
• ­­­­­­­­The novel designer cytokine IC7Fc protects against obesity-induced metabolic disease - Mark Febbraio
• Hepatokines: linking fatty liver to diabetes - Matthew Watt
• Emerging Roles of MAP kinase phosphatases in Metabolic Homeostasis - Anton Bennett

• Facilitating change in retail settings covering government, small stores and supermarkets. - Joel Gittelsohn
• The facilitators and barriers to implementation from the experience of government in settings under their control. - Megan Cobcroft
• What else can be implemented to enhance policy outcomes including pricing, labelling, placement and product. - Anna Peeters
• The experience of Wester Leisure Services in improving the nutritional value of the food supply from a business perspective. - Carson Brooks
• Engaging food businesses in healthy eating initiatives: lessons from the UK - Tara Boelsen-Robinson

• Cellular Energy Sensing and Metabolism:  Implications for Treating Obesity - Gregory Steinberg
• What should we over-eat? - David James
• The diverse obesity phenotypes – Implication for treatment   - Dorit Samocha-Bonet
• Disruption of AMPK-glycogen binding in vivo reveals novel roles in whole-body and tissue metabolism - Nolan Hoffman
• Muscle membrane permeability to glucose and blood flow explain increased insulin sensitivity in muscle after exercise - Glenn K McConell

• Time restricted feeding - Leonie Heilbronn
• Alternating periods of energy restriction and energy balance - Amanda Sainsbury-Salis
• Circadian rhythms, diet and exercise - John Hawley
• Effect of Intermittent compared with Continuous Energy Restriction on Glycaemic Control in Patients with Type 2 Diabetes - Peter Clifton
• Effects of time-restricted feeding on mood, hunger and fatigue - Evelyn B Parr

• “It would definitely make you think twice, even after you’ve finished the drink, it’s in your car, like the empty bottle, you’d look at it”: Young adults’ reactions to warning labels on the bottles of sugary drinks. - Kerry Ettridge
• Frequency of price promotions on food in a major Australian supermarket chain: analysis by food category and relative product healthiness - Devorah Riesenberg
• The potential cost-effectiveness of regulatory restriction on price promotions of carbonated sugary beverages in Australia - Oliver Huse
• Cost-effectiveness of the Victorian sugary drink public education mass media campaign: a modelled analysis - Nikki McCaffrey
• Can front-of-pack nutrition labels overcome any biasing effects of nutrient and health claims? - Zenobia Talati
• Reporting on key nutrition indicators as a decision support tool to improve diet quality in remote Indigenous Australian communities - Emma McMahon
• Obesity and Increased Cancer Risk: The Development of a Public Health Education Campaign. - Alice Bastable
• Simulated economic impacts of Australian Obesity Management Algorithm implementation:  microsimulation modelling to 2030 - Sharyn Lymer

• The role of the pro-apoptotic protein BIM in glucose homeostasis and preservation of islet mass in type 2 diabetes - Helen Thomas
• IL-22-based tissue-targeted therapeutics for type 2 diabetes - Michael McGuckin
• The interplay between insulin and the NPY system - Kim Loh
• Cafeteria diet-induced cognitive impairment is prevented by oral minocycline in association with changes in the microbiome - Sarah-Jane Leigh
• Genetic architecture of a healthy diet in Drosophila - Essi Havula

• Metformin and dietary advice for pregnant women who are overweight or obese: the GROW randomised trial. - Jennie Louise
• The importance of good dialogue between healthcare professionals and people with obesity - John Dixon
• Real-world clinical effectiveness of liraglutide 3.0 mg for weight management in Canada - Samantha Hocking
• Comparison of clinicians’ views for managing children with obesity in the primary, secondary and tertiary settings - Jennifer Cohen
• SERVICE PROVIDES; THE ADOLESCENT DECIDES: WEIGHT LOSS OUTCOMES IN A TERTIARY OBESITY SERVICE - Alicia Grunseit
• Early adolescent weight gain and its relationship to the tempo and timing of puberty - Hoi Lun (Helen) Cheng
• Early clinical markers of overweight/obesity onset and resolution by adolescence: Longitudinal Study of Australian Children - Kate Lycett
• Longitudinal association of a body mass index (BMI) genetic risk score with growth and BMI changes across the lifecourse - Marie-Jeanne Buscot

• Distinct populations of Arc NPY neurons control specific aspects of energy homeostasis - Qi Yue
• Differential benefits of two isocaloric exercise programs on diet-induced non-alcoholic fatty liver disease and circulating extracellular vesicles in mice - Linda A Ban
• Vertical sleeve gastrectomy and hypertension in diet-induced obese rodents  - Denovan P Begg
• A systematic research review of associations between maternal eating disorders and parent-child feeding interactions - Heidi Bergmeier
• Recovery from sucrose-induced metabolic and cognitive impairments in male rats. - Robert A Boakes
• Metformin administration in pregnant high-fat fed rats improves metabolic function and adiposity - Jessica F Briffa
• N-acetylcysteine reduces 'addiction-like' behaviour towards high-fat high-sugar food in diet-induced obese rats. - Diana Sketriene
• The transgenerational effects of obesogenic diets. - Tara-Lyn Carter
• Effect of intermittent fasting on autophagy in human and C57BL/6 mouse muscle. - Rajesh Chaudhary
• Modulation of gastric vagal afferent satiety signalling by endocannabinoids - Stewart Christie
• Effect of whole foods and dietary patterns on markers of subclinical inflammation in weight stable overweight and obese adults – A Systematic Literature Review - Stephanie Cowan
• Periodontal bone loss is not modulated by weight gain in an experimental mouse model of periodontitis - Joerg Eberhard
• The designer cytokine IC7Fc improves metabolic homeostasis in db/db mice - Maria Findeisen
• Cognitive control of reward neurocircuitry in the activity-based anorexia rat model - Claire J Foldi
• The Role of Amyloid Beta₄₂ in Heart Disease - Liam G Hall
• Why do some mice resist weight gain on a high caloric diet? An omics approach. - Darren Henstridge
• Fatty acid binding protein 4 inhibitor corrects metabolic disturbance in MKR mouse of Type 2 diabetes - Lili Huang
• Metabolic effects of mirabegron in primary adipocytes in vitro, and on metabolic parameters in vivo - Dana S Hutchinson
• Coordinated activation of central amygdala - arcuate nucleus NPY circuits are required for the development of stress-induced obesity - Chi Kin (Kenny) Ip
• Development of Biomarkers for protein malabsorption and in vivo inhibition of B⁰AT1(SLC6A19). - Kiran Javed
• The role of Nox5 in diabetic complications - Jay C Jha
• Adiposity and spatial memory impairments are determined by the pattern of access to high-fat, high-sugar ‘cafeteria’ diet in rats - Michael Kendig
• The effect of ACE I/D polymorphism on the expression of fatty acid oxidation-related genes in human skeletal muscle after a single session of high-intensity interval exercise - Amit Khatri
• Hepatocyte-specific deletion of Nox4 induces whole-body insulin resistance - Robert Lee
• Inhibition of AMPK-HMGCR signaling promotes the development of atherosclerosis and hepatic steatosis   - Kim Loh
• Potential actions of a Chinese herbal formula for obesity - Shiqi Luo
• Inhibition of palmitic acid-induced hepatic steatosis and inflammation with Tempol - Gihani Manodara
• Constant-moderate and high-intensity interval training induce contrasting metabolic effects in high-fat fed mice - Sergio F Martinez Huenchullan
• SGLT-2 inhibitor induced sympathoinhibition: a novel mechanism for cardiorenal protection. - Vance B Matthews
• The Impacts of Blueberry, Yoghurt, Cyanidin-3-O-β-Glucoside and Peptides Extracted from Yoghurt on High-fat-high-carbohydrate Induced Obese Mice - Andrew J McAinch
• Characterization of AgRP neurons knock out mouse for the Carnitine palmitoyl transferase 1a (CPT1a) - Mathieu Méquinion
• Metabolic characterisation of knock-in mice harbouring the ‘obesity variant’ of CREBRF - Louise K Metcalfe
• Potential mechanisms of skeletal muscle insulin resistance in women with PCOS: a pilot study - Alba Moreno-Asso
• Expression of nutrient sensing mechanisms in the mouse stomach - Maria Nunez-Salces
• The impact of acute and chronic L-isoleucine supplementation on body weight and glucose tolerance in standard and high fat diet induced-obese mice. - Rebecca O'Rielly
• Obesity during pregnancy in rats adversely influences brain function in the offspring as adults - Helena C Parkington
• Non-humanoid primate model of diet-induced obesity: model validation for biomarker discovery - George Pauls
• Effects of high-intensity interval training performed in the morning or evening on 24 h blood glucose profiles - Samuel K Pinto
• Bingeing on sweet drinks: Persistent elevated intakes in rats - Simone Rehn
• Bone marrow transplantation and RNAseq analysis of Gpr21^-/-monocytes reveals reduced migratory function and downregulation of inflammatory genes - Darren M Riddy
• Stabilization of Beta Catenin in hypothalamic cell lines - Mohammed Z Rizwan
• Glycoprotein acetyls (GlycA) associate with BMI and co-morbidities in childhood obesity - Christoph CS Saner
• Lower prevalence of performance genes are linked with increased severity of obesity in youth - Christoph CS Saner
• The Impacts of Cyanidin-3-O-β-Glucoside and Peptides Extracted from Yoghurt on Glucose Uptake and Gene Expression in Human Primary Skeletal Muscle Cells from Obese and Diabetic Individuals - Min Shi
• Peripheral NPY antagonism reduces HFD-induced adiposity and improves glucose tolerance in ageing mice - Yan-Chuan Shi
• The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model. - Anna C Simcocks
• The likely role of brown adipose tissue as a mediator of improved glucose regulation after vertical sleeve gastrectomy - Aneta Stefanidis
• Complement C5a receptor 1 (C5aR1) modulates mitochondrial fatty acid oxidation and cardiolipin remodelling leading to diabetic kidney disease - Sih Min Tan
• Targeting skeletal muscle ceramides to alleviate glucose intolerance - Sarah Turpin-Nolan
• Determining the metabolic impact of dietary carbohydrate composition in the setting of low, medium and high protein diets. - Jibran A Wali
• Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease - Kelly L Walton
• Regulation of Lipid Metabolism in Skeletal Muscle by IDOL - Yi Wang
• Combining intermittent fasting with high intensity interval training reduces fat mass by increasing fat oxidation and mobilization. - Robin A Wilson
• Does activation of TRPM8 with menthol or icilin reduce blood glucose and body weight? - Rachael Wu
• Muscle-specific NOX4 deficiency impairs antioxidant defence, mitochondrial biogenesis and exercise capacity - Chrysovalantou E Xirouchaki
• Amino acid restriction through B⁰ATI (Slc6a19) Inhibition: A potential target for treating diabetes - Aditya Yadav
• NOX4 deficiency impairs insulin sensitivity - Chieh-Hsin Yang
• Essential amino acid restriction dictates the systemic metabolic response to dietary protein dilution - Yann Yap
• Legacy effects of high fat preconditioning against metabolic syndrome with enhanced metabolic capacity in muscle and adipose tissue - Jiming Ye
• Do exercise and NMN provide synergistic benefits in obese mice? - Josephine Yu
• Molecular docking study of cassia seed compounds to identify amylase and lipase inhibitors for weight management - Heidi Yuen
• Metabolic detection of energy deficit by Crat in AgRP neurons links hunger with reward - Alexander Reichenbach
• Gastric Band Tubing causing Caecal Volvulus - Joseph Do Woong Choi
• Persistent leptin signalling in the arcuate nucleus reduces insulin’s capacity to suppress hepatic glucose production in obese mice. - Eglantine Balland
• Crosstalk between hypothalamic leptin and insulin signalling in obesity - Christine Ishak

Sex and menstrual cycle modulate cold- and meal-induced brown adipose tissue activity in humans - John-Paul Fuller-Jackson

Perilipin 5 deletion in hepatocytes remodels lipid metabolism and causes hepatic insulin resistance in mice - Stacey N Keenan

Hunger-sensing AgRP neurons engage the hypothalamic-pituitary-adrenal axis to mediate adaptive responses to stress - Rachel Clarke

PSMD9 identified as a novel regulator of hepatic acylglycerol metabolism using an integrated systems-biology approach - Michael F Keating

• Brain Control of Blood Glucose - Michael Cowley
• Obesity pharmacotherapy in clinical practice - Kirsi Pietilainen
• Pharmacotherapy in managing psychotropic weight gain and metabolic syndrome in people with mental illness - Marlene Tham
• Treatment of type 2 diabetes in people with obesity - Georgia Soldatos

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